2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-153995A
    D-Ribonic acid 642-98-8 98%
    D-Ribonic acid is a metabolite of D-Ribose (HY-113375). Ribonic acid is associated with genetic variations in ENOSF1 and NUBPL. Ribonic acid may participate in the mitochondrial energy production process.
    D-Ribonic acid
  • HY-17412S1
    Minocycline-d6 sulfate
    Minocycline-d6 sulfate is deuterated labeled Minocycline (HY-17412A). Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect.
    Minocycline-d6 sulfate
  • HY-177662B
    Scrambled Sapablursen
    Scrambled Sapablursen is a sequence disorder of Sapablursen (HY-177662). Scrambled Sapablursen is inactive and can be used as a negative control for Sapablursen.
    Scrambled Sapablursen
  • HY-A0132S7
    N-Acetyl-D-glucosamine-15N 478518-85-3 99.9%
    N-Acetyl-D-glucosamine-15N is the 15N labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of gluc.
    N-Acetyl-D-glucosamine-15N
  • HY-B0188AR
    Mianserin hydrochloride (Standard) 21535-47-7 98.72%
    Mianserin hydrochloride (Org GB 94) (Standard) is the analytical standard of Mianserin hydrochloride. This product is intended for research and analytical applications. Mianserin hydrochloride is an orally active H1 receptor antagonist. Mianserin hydrochloride can activate κ-opioid receptor and octopamine receptor. Mianserin hydrochloride increases ERK1/2 and CREB phosphorylation, and antagonizes full κ-opioid agonist and Dynorphin A (HY-P1333)-induced MAPK phosphorylation. Mianserin hydrochloride modulates social and exploratory behaviour, raises electroconvulsive thresholds. Mianserin hydrochloride can be used for the research of neurological disease, such as depression and epilepsy.
    Mianserin hydrochloride (Standard)
  • HY-B0260S6
    Methylprednisolone-d3-1 2280940-15-8
    Methylprednisolone-d3-1 (U 7532-d3-1) is the deuterium labeled Methylprednisolone (HY-B0260). Methylprednisolone (U 7532) is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels.
    Methylprednisolone-d3-1
  • HY-B0345AS
    ATP-18O4 sodium 2483830-61-9
    ATP-18O4 (disodium salt) is the 18O labeled ATP disodium salt. ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation.
    ATP-18O4 sodium
  • HY-B1776AR
    Spermidine hydrochloride (Standard) 334-50-9 99.61%
    Spermidine (hydrochloride) (Standard) is the analytical standard of Spermidine (hydrochloride). This product is intended for research and analytical applications. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents.
    Spermidine hydrochloride (Standard)
  • HY-B2130AR
    Uric acid sodium (Standard) 1198-77-2 99.88%
    Uric acid (sodium) (Standard) is the analytical standard of Uric acid (sodium). This product is intended for research and analytical applications. Uric acid sodium (Monosodium urate), scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid sodium can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation.
    Uric acid sodium (Standard)
  • HY-B2219S1
    Stearic acid-d2 19905-58-9 99.12%
    Stearic acid-d2 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
    Stearic acid-d2
  • HY-N0305S2
    5-Aminolevulinic acid-13C hydrochloride 98%
    5-Aminolevulinic acid-13C (hydrochloride) is the 13C labeled 5-Aminolevulinic acid hydrochloride. 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.
    5-Aminolevulinic acid-13C hydrochloride
  • HY-N7032S1
    Uridine 5′-diphosphoglucose-13C6 disodium 2483735-04-0 98.35%
    Uridine 5′-diphosphoglucose-13C6 (UDP-D-Glucose-13C6) disodium is the 13C labeled Uridine 5′-diphosphoglucose disodium (HY-N7032). Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue.
    Uridine 5′-diphosphoglucose-13C6 disodium
  • HY-P990805
    Anti-Human/Mouse GRP78 Antibody (C38)
    Anti-Human/Mouse GRP78 Antibody (C38) is a kind of mouse IgG2b antibody inhibitor, targeting to GRP78. Anti-Human/Mouse GRP78 Antibody (C38) inhibits RhoA, ROCK and AKT activation. Anti-Human/Mouse GRP78 Antibody (C38) can be used for the researches of cancer and metabolic disease, such as melanoma and diabetes.
    Anti-Human/Mouse GRP78 Antibody (C38)
  • HY-P990808
    Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1)
    Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) is a rat-derived IgG2b κ type antibody inhibito, targeting to mouse CD122/IL-2Rβ. Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) can block IL-2 and IL-15. Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) can deplete natural killer (NK) cells and NKT cells. Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) can be used for the researches of cancer, infection, inflammation, immunology and metabolic disease, such as melanoma, experimental autoimmune encephalomyelitis (EAE) and diabetes.
    Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1)
  • HY-RS00001
    ACE2 Rat Pre-designed siRNA Set A

    ACE2 Rat Pre-designed siRNA Set A contains three designed siRNAs for ACE2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    ACE2 Rat Pre-designed siRNA Set A
  • HY-RS16293
    Lrp6 Mouse Pre-designed siRNA Set A

    Lrp6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lrp6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Lrp6 Mouse Pre-designed siRNA Set A
  • HY-RS16307
    mt-Nd4 Mouse Pre-designed siRNA Set A

    mt-Nd4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for mt-Nd4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    mt-Nd4 Mouse Pre-designed siRNA Set A
  • HY-RS16955
    Ucp1 Mouse Pre-designed siRNA Set A 98%

    Ucp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ucp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ucp1 Mouse Pre-designed siRNA Set A
  • HY-RS29447
    Plin4 Mouse Pre-designed siRNA Set A
    Plin4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Plin4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Plin4 Mouse Pre-designed siRNA Set A
  • HY-RS29463
    GCNT4 Mouse Pre-designed siRNA Set A
    GCNT4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for GCNT4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Components
    GCNT4 siRNA-1: 5 nmol (HPLC)
    GCNT4 siRNA-2: 5 nmol (HPLC)
    GCNT4 siRNA-3: 5 nmol (HPLC)
    siRNA Negative Control: 5 nmol (HPLC)
    FAM-labeled siRNA Negative Control: 5 nmol (HPLC)
    GAPDH siRNA Positive Control: 5 nmol (HPLC)
    GCNT4 Mouse Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Application Reactivity